Tag Archives: cellular

Mechanisms Underlying Dedifferentiation and Tumorigenesis

Faculty Information Faculty Name: Myon-Hee Lee Department: Medicine Contact Information: leemy@ecu.edu; 252-744-3134   Research Description Highlights of Research:  Dedifferentiation is the reverse developmental process in which differentiated cells with specialized functions revert to a more undifferentiated and multipotent cells. This process is important for replacing a lost stem cell population and has been implicated in the formation of tumor-initiating cells

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Protein Effect on Germline Stem Cells

Faculty Information Faculty Name:            Brett D. Keiper, PhD Department:              Biochemistry & Molecular Biology Contact Information:   Tel: (252) 744-2656     Lab: (252) 744-2693 ;  keiperb@ecu.edu http://www.ecu.edu/cs-dhs/biochemistry/Faculty-Keiper.cfm   Research Description Highlights of Research: The research in my lab studies mRNA translation in developing germ cells (sperm and eggs). The purpose is to see how protein synthesis is subtly regulated to cause

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How Do Mitochondrial Respiratory Proteins Work?

Faculty Information Faculty Name:                    Tonya Zeczycki Department:                       Biochemistry and Molecular Biology Contact Information:           zeczyckit@ecu.edu, East Carolina Heart Institute Rm. 4400   Research Description Highlights of Research: The allosteric regulation of enzyme activity is fundamental to preventing metabolic and homeostatic chaos. A colossal number of complex, multifunctional enzymes important to metabolic and cellular processes exhibit some form of

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Cellular Posttranscriptional Response to Hypoxia

Faculty Information Faculty Name: Kyle D. Mansfield Department: Biochemistry and Molecular Biology, Brody School of Medicine Contact Information: mansfieldk@ecu.edu; 744-5519; Room 5S-10 Brody   Research Description Highlights of Research: Oxygen limitation, or hypoxia, is a key component of many diseases and includes periods of acute ischemia such as arise during stroke, as well as more persistent hypoxia like that which

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