ANCA-associated vasculitis presents the physician with a set of challenging and non-ideal therapeutic options. ANCA-associated vasculitides that are refractory to conventional therapy (namely, cyclophosphamide induction) are next best treated with rituximab (an anti-CD20 antibody). This randomized control trial now addresses the effectiveness of rituximab therapy as a first line agent in the treatment of ANCA-associated vasculitides.

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***See related teaching resources:
1. Induction Therapy for ANCA-associated vasculitis: Pulse vs. Intravenous Cyclophosphamide
2. ANCA-associated vasculitis: A review

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Time Required (estimated): 20 minutes
Title: Rituximab versus Cyclophosphamide in ANCA-associated Renal Vasculitis
Citation: NEJM 2010, Volume 363, pp. 211-20
Date Created: 2010
Revisions: None Indicated
Disclaimers: Cambridge University Hospitals National Health Service Foundation Trust and F. Hoffman-La Roche (see p. 212)
Resource Type: Text

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Rituximab v Cyclophosphamide for Induction in ANCA-associated vasculitis — The RITUXIVAS Trial, 9.2 out of 10 based on 1 rating
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