It is well known that the renin-angiotensin-aldosterone system (RAAS) has negative influence on blood pressure, heart failure and overall cardiovascular risk. Now, an increasing body of evidence show that the RAAS has a negative role in cell proliferation, angiogenesis, and tumor progression. This meta-analysis of randomized controlled trials helps place the RAAS’ influence on tumor progression in proper perspective.

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Time Required (estimated): 30 minutes
Title: Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials
Citation: Lancet Oncology 2010, Volume 11, pp. 627-36
Date Created: 2010
Revisions: None Indicated
Disclaimers: Pfizer, Astra-Zeneca, Ranbaxy, among other sponsors (see page 635)
Resource Type: Text
Other: Presented by Dr. Reginald Obi at ECU Nephrology Journal Club on 10/19/10

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