Archives: September 20 – 27, 2010

2010 Peritoneal Dialysis Academy Seminars — BLOGGING BEGINS SEPTEMBER 23

Join physician-blogger Dr. Sarath Kolluru at the 2010 Peritoneal Dialysis Academy in Birmingham, Alabama. Dr. Kolluru will be blogging about the highlights of the meeting, including new scientific data regarding all aspects of peritoneal dialysis.

A must-read blog for anyone interested in learning more about PD but unable to attend the seminars. Find his blog by clicking here

Dr. Kolluru will be available to answer your questions online.

*** Note: Only registered users can participate in the virtual discussion. Not a registered user but interested in becoming one? Click here to complete our quick registration form.

Monthly Nephrology Journal Club — SEPTEMBER 21

Join the ECU Division of Nephrology and Hypertension for its monthly Journal Club. This month’s topics are:

Early vs. Late Initiation of Dialysis in CKD-V Patients by Dr. Sarath Kolluru
Effect of Allopurinol on Chronic Kidney Disease and Cardiovascular Events by Dr. Lakshmi Turlapati

Drs. Kolluru and Turlapati will present these randomized clinical trial and be available to answer your questions online.

To access the article (Early v. Late Initiation…), click here.

To access the article (Effect of Allopurinol…), click here

*** Note: Only registered users can participate in the virtual discussion. Not a registered user but interested in becoming one? Click here to complete our quick registration form.

Public Service Announcement

**If you would like to submit a resource to Nephrology On-Demand, please visit our Submit a Resource Page for more information

International Pediatric Nephrology Association (IPNA) — NOW AVAILABLE

The 15th Annual International Pediatric Nephrology Association meetings will be held from August 29 – September 2, 2010 in New York, NY. Nephrology On-Demand will bring you highlights of the meetings and special sessions.

Click here to participate in the highlights and provide your thoughts/comments about the topics discussed at IPNA.

*** Note: Only registered users can participate in the virtual discussion. Not a registered user but interested in becoming one? Click here to complete our quick registration form.

Faster Rating System of Teaching Resources

One of our goals is to provide you with an opportunity to grade teaching resources found on Nephrology On-Demand. These grades help future users discern quality teaching resources and help users manage their time more effectively.

Along with our 6-point review system known as Transparent Peer Review, we have included a quick 5-star review system at the top of every teaching resource. All users can grade teaching resources using this quick tool and, if needed, can provide a more extensive evaluation of a resource using Transparent Peer Review.

Nephrology On-Demand encourages you to grade our teaching resources to help us make a more educational website for you in the months to come!

Puzzle of the Week ACID-BASE DISORDERS

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  • 1. Commonly used acronym to remember the causes of anion gap metabolic acidoses
  • 2. The amino acid from which ammonia is generated
  • 3. The acronym for a weak base that binds both CO2 and H+ -- it theoretically limits the amount of CO2 that can diffuse intracellularly and decrease intracellular pH
  • 4. This mathematical calculation estimates the amount of ammonia generated by the kidney during an acidosis (___--___--___)
  • 5. The proximal convoluted tubule maintains acid/base balance primarily through its reabsorption of this species
  • 6. The section of the nephron where urinary **pH** is primarily controlled (i.e., a defect in this portion of the nephron will lead to an elevated urinary pH)
  • 7. Ingestion of this compound cause an acquired deficiency in 11 beta-hydroxylase activity
  • 8. In an acidosis, the administration of intravenous bicarbonate solution should yield a fractional excretion of bicarbonate (FE-HCO3) of less than 5% EXCEPT in this RTA
  • 9. The following law of physical chemistry states that for any change in PCO2 of HCO3-, there must be a concomitant change in the other species such that if NO CHANGE were to occur, there must be a second acid/base disturbance (___-__-____-____)
  • 10. The most common pathophysiologic mechanism by which respiratory alkalosis occurs
  • 11. In experimental models, the administration of intravenous bicarbonate to animals with lactic acidosis leads to an improvement in serum pH but worsening in overall condition as a result of a paradoxical intracellular increase of this species (___-____)
  • 12. A common complication of distal RTA's not found in proximal or type IV RTA's


  • 13. pH measurements on a common urine dipstick are INACCURATE measurements and cannot be used to accurately measure urinary pH
  • 14. The physiologic response to an acid-base disturbance which partially returns pH to normal
  • 15. Acidosis occurring in the absence of diarrhea and in the setting of normal kidney function with a normal anion gap (___-___-___)
  • 16. In this acid/base condition, organic H+ are generated (_____-______)
  • 17. The only renal tubular acidosis (RTA) that commonly leads to hyperkalemia
  • 18. This mathematical calculation implies that for every 1 mmol of H+ generated in the serum, an equaly amount of bicarbonate is eliminated from the serum (________-_________)
  • 19. Defect in the generation of this species is the common denominator in all forms of renal tubular acidoses
  • 20. Each 650 mg tablet of sodium bicarbonate has the following number of mEq of bicarbonate
  • 21. Urinary ammonia (NH3) is a titratable acid
  • 22. An agent that enhances pyruvate dehydrogenase and thereby helps metabolize lactate into compounds that can easily enter the tricarboxylic acid (TCA or Krebs) cycle
  • 23. Type of renal tubular acidosis (RTA) that primarily occurs because of an inability to reclaim filtered bicarbonate
  • 24. Number of distinct types of distal renal tubular acidoses
  • 25. A defect in the ability to secrete H+ leads to this form of distal RTA
  • 26. The acronym for the mathematical formula that compares the amount of K+ in the urine versus the amount of K+ in the serum, but is only accurate if the amount of urinary Na+ is > 25 meq/L
  • 27. Bicarbonate is preferentially reabsorbed because of a loss of this anion in a metabolic alkalosis (saline-responsive)

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Abstract Submissions — UPDATED SEPTEMBER 19, 2010

Keep your eyes on Nephrology On-Demand for more information on the following meetings:

International Forum on Quality and Safety in Healthcare — Abstract Deadline September 24, 2010
NKF Spring Clinical Meeting 2011 — Abstract Deadline December 3, 2010
North American Society for Dialysis and Transplantation 2010 — Abstract Deadline May 28, 2010
Southern Society for Clinical Investigation 2011 — Abstract deadline expected to be October 2010
ACP Medical Student Abstract Competition 2011 — deadline expected to be early-December 2010
ACP Resident and Fellows Abstract Competition 2011 — expected deadline not yet announced; check back in August 2010 for more information
ISN Abstract Competition 2011 — expected deadline not yet announced
American Transplant Congress 2011 — expected to be open in September 2010
International Society of Blood Purification — Abstract Deadline July August 30, 2010
Evidence 2010 — Abstract Deadline August 6, 2010
American Federation of Medical Research: Southern Regional Meetings — Abstract Deadline October 15, 2010
American Federation of Medical Research: Western Regional Meetings — Abstract Deadline October 1, 2010

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