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Archives: October 14 – 21, 2010

Internal Medicine Grand Rounds — NOW AVAILABLE

The Department of Medicine at East Carolina University held it’s weekly Internal Medicine Grand Rounds on October 8, 2010. Dr. Paul Bolin discussed the following topic:

Hypertension Revisited – 2010

You can see the presentation by clicking here.

Dr. Bolin will be taking your questions and comments.

*** Note: Only registered users can participate in the virtual discussion. Not a registered user but interested in becoming one? Click here to complete our quick registration form.

Monthly Nephrology Journal Club — OCTOBER 19

Join the Division of Nephrology and Hypertension for our monthly journal club. Dr. Reginald Obi will be presenting:

Angiotensin Receptor Blockade and the risk of Cancer

The article will be available on October 15 by clicking here.

*** Note: Only registered users can participate in the virtual discussion. Not a registered user but interested in becoming one? Click here to complete our quick registration form.

Quarterly Statistics — NOW AVAILABLE

Each calendar quarter we bring you new statistics to let you know how successful Nephrology On-Demand has become. This quarter, we present data illustrating the types of users accessing this website.

To date, Nephrology On-Demand has 181 registered users. See the graphs below to compare the our registered and total user groups.

Puzzle of the Week — HYPERTENSION REVISITED – 2010

This interactive crossword puzzle requires JavaScript and a reasonably recent web browser, such as Internet Explorer 5.5 or later, Netscape 7, Mozilla, Firefox, or Safari. If you have disabled web page scripting, please re-enable it and refresh the page. If this web page is saved to your computer, you may need to click the yellow Information Bar at the top of the page to allow the puzzle to load.

Questions

Across

1. In 1980, this iteration of the JNC criteria recommend 4 classes of antihypertensive therapies: 1) diuretics, 2) adrenergic inhibiting agents, 3) vasodilators, and 4) additional adrenergic inhibiting agents (Archives of Internal Medicine 1980, Volume 140, p. 1280)
2. It was not until the 4th iteration of the JNC guidelines (1988) that this well-known class of anti-hypertensive drugs were added to the algorithm for treating essential hypertension (___-___) (Archives of Internal Medicine 1988, Volume 148, p. 1028)
3. At one point in time (2005), this drug was the 4th most prescribed drug in the US. As of 2009, it is the 19th most prescribed drug
4. Atenolol is thought to not exert a tremendous effect on the pathophysiology of essential hypertension because of it's inability to block synthesis of this hormone (American Journal of Hypertension 2010, Volume 23, pp. 1014)
5. As of January 2010, there have been this number of iterations of the JNC guidelines for diagnosing and treating essential hypertension
6. Acronym of the trial that showed a benefit in composite renal outcomes with intensive blood pressure control in patients with proteinuria (NEJM 2010, Volume 363, p. 918)
7. In all iterations of the JNC criteria for hypertension, this is the first therapeutic option in treating ANY stage of hypertension (___-____)
8. A meta-analysis in 2009 showed that when comparing atenolol to any other anti-hypertensive medication, a variety of outcomes are improved by the use of atenolol over the other medication (JACC 2009, Volume 53, p. 2101)
9. One of the first class of medications used in the modern era to control hypertension (NEJM 1949 p. 173)
10. In 1991, a J shaped association was shown between hypertension and this cardiovascular outcome (____-____) (JAMA 1991, Volume 265, p. 489)
11. As early as 1940 there was little to no prevention of hypertension

Down

12. According to the 7th iteration of the JNC criteria, this stage is defined as a systolic BP of 120-139 mmHg or diastolic BP of 80-89 mmHg and should only be treated with lifestyle modification.
13. Franklin D. Roosevelt, who suffered from hypertension, especially diastolic hypertension, eventually died from this complication of high blood pressure (____-____)
14. The acronym of the trial, currently underway at East Carolina University, that is comparing two drug treatment strategies: sBP < 140 mmHg or sBP < 120 mmHg using either thiazide and/or ACE-inhibitors/ARB's to assess MI, stroke, hospitalizations, heart failure, or cardiovascular death
15. The first line of therapy for patients with stage 1 hypertension (sBP 140-159 or dBP 90-99) according to JNC-7 criteria
16. The acronym for the randomized trial that showed no difference in composite cardiovascular outcomes in type 2 diabetic patients who received intense blood pressure control than