Archive: January 18 – 24, 2011

Nephrology Journal ClubNOW AVAILABLE

Join the ECU Division of Nephrology and Hypertension as we take an in-depth look at statin therapy in CKD and ESRD patients. This month’s comprehensive journal club, presented by Drs. Sarath Kolluru and Tejas Desai, will focus on the following clinical trials:

  1. GRAECE,
  2. Pravastatin Pooling Project,
  3. 4D Study,
  4. AURORA Trial,
  5. CARDS, and
  6. SHARP Trial

Teaching resources are now available. Comments are welcome on Nephrology On-Demand and/or NOD Facebook.

Health Care Transition – 2010 Year-in-Review –NOW AVAILABLE

The International Society of Health Care Transition (ISHCT) is focused on caring for young adolescents who are entering adulthood with kidney disease. Exclusive for Nephrology On-Demand users, the 2010 Year-In-Review presentation is now available. View it here.

Medical Student Summer Research at Vanderbilt University — Registration closes March 15

Medical students interested in research in Nephrology and/or Hypertension are encouraged to apply for the Summer Medical Student Research Program at Vanderbilt University. A stipend is provided and research can be conducted in both clinical and basic science areas.

For more information and registration details visit:

Nephrology In-Training Examination — Registration is now open

Registration for the ASN In-Training Examination in Nephrology (ITE) is now open and can be found here.


Join us on January 28, 2011 as the Editorial and Programming Boards for Nephrology On-Demand present a detailed look at the 2010 version of this website. In-depth data will be presented showing how NOD operates and where the potentials for growth exist.

There will be 4 ways for you to comment:

  1. through this website (only for registered users)

  2. through our 2010 Survey (all users)

  3. through our Facebook page

  4. through our Twitter page

As always, we welcome your comments.

Puzzle of the Week Adequacy in Hemodialysis – A Review of NCDS, HEMO, and FHN Trials

This interactive crossword puzzle requires JavaScript and a reasonably recent web browser, such as Internet Explorer 5.5 or later, Netscape 7, Mozilla, Firefox, or Safari. If you have disabled web page scripting, please re-enable it and refresh the page. If this web page is saved to your computer, you may need to click the yellow Information Bar at the top of the page to allow the puzzle to load.



  • 1. The measurement used to assess dialysis adequacy in the NCDS (NEJM 1981, Volume 305, p. 1176) (__-_-_-___)
  • 2. In the HEMO Trial, the clearance of this middle molecular weight molecule was used to measure dialyzer flux ______-_-_______ (NEJM 2002, Volume 347, p. 2010)
  • 3. A major limitation in the use of the TAC(urea) as a measure of dialysis adequacy is that if can fluctuate based on _______-______ intake (NEJM 1981, Volume 305, p. 1176)
  • 4. Of the 9 secondary outcomes measured, 8 showed improvement when a higher ____ was achieved (NEJM 2002, Volume 347, p. 2010)
  • 5. Flux refers to the ease at which __ can cross the dialyzer membrane


  • 6. This parameter is an inaccurate measurement of dialysis adequacy, as indicated by the National Cooperative Dialysis Study (NEJM 1981, Volume 305, p. 1176)
  • 7. Acronym of one of the earliest studies to look at hemodialysis adequacy (NEJM 1981, Volume 305, p. 1176)
  • 8. This variant of the kT/V accounts for the rebound of urea from the intracelluar compartment during dialysis
  • 9. One limitation of the NCDS was that patients with this common co-morbidity were excluded from the study (NEJM 1981, Volume 305, p. 1176)
  • 10. In the FHN Trial, death was not measured by itself, but rather was a part of two separate _-_______ outcomes ((NEJM 2010, Volume 363, p. 2287)
  • 11. The HEMO Trial randomized patients into low and high kT/V (urea) or low and high _______-_______ (NEJM 2002, Volume 347, p. 2010)
  • 12. An alternate from of the equilibrated kT/V was used in the FHN Trial to offset the dependence of dialysis prescriptions on body mass (NEJM 2010, Volume 363, p. 2287)
  • 13. In an analysis of the secondary outcomes, death showed a statistically significant improvement in the group receiving hemodialysis six times per week ((NEJM 2010, Volume 363, p. 2287)

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