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Author Topic: Dosing mucomyst for a CKD patient receiving a cardiac catheterization
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Post Dosing mucomyst for a CKD patient receiving a cardiac catheterization
on: July 21, 2011, 09:01
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How would you dose mucomyst for a CKD stage III patient who will be receiving a cardiac catheterization?

Thanks.

Nurse Practitioner

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Post Re: Dosing mucomyst for a CKD patient receiving a cardiac catheterization
on: July 21, 2011, 09:45
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I'm assuming your patient is an outpatient.

If so, most physicians would administer anywhere between 600 mg to 1200 mg twice a day for a total of 4 doses. This is based on the following trial: J Am Coll Cardiol 2002;40:298-303. In this study, the investigators found that the higher dose of mucomyst (1200 mg BID) had a statistically significant effect at lowering rates of contrast-induced nephropathy when the patient was receiving high doses of contrast (> 140 ml). Keep in mind that:

  • the patients had an eGFR of less than 60
  • all the patients received IVF (in this case, 0.45% NaCl

I think the better way to protect against contrast-induced nephropathy would be to administer IVF's rather than focus on the dosing of mucomyst.

Junior faculty

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