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Author Topic: Soluble EPO receptors

Posts: 219
Post Soluble EPO receptors
on: January 7, 2012, 10:08

out of curiosity, would you or any of your nephrology links know if soluble EPO receptors are dialysable?


Posts: 219
Post Re: Soluble EPO receptors
on: January 7, 2012, 10:17

Soluble EPO receptors range from 27,000 to 34,000 daltons, depending on the degree of glycosylation. As a reference, beta-microglobulin is 11,000 daltons and albumin is 66,400 daltons.

Most low-flux dialyzers would not clear beta-microglobulin, and thus not clear soluble EPO receptors as well.

High-flux dialyzers, however, can clear beta-microglobulin, but not albumin. Thus, the answer to your question will rest on the type of dialyzer you are using. The manufacturer should specify (in the package insert), the dalton size that it can clear.

Other factors to consider in the clearance of soluble EPO receptors are:
1. volume of distribution
2. half-life of the soluble receptor
3. degree of protein-binding

I hope this helps. For further information click here.

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