Discussion Board


Registration is recommended, but not required, to use the Nephrology On-Demand Discussion Board.


Welcome Guest 

Show/Hide Header

Welcome Guest, please login or register.

Pages: [1]
 ReplyRSS feed   
Author Topic: Soluble EPO receptors
Guest

Posts: 176
Permalink
Post Soluble EPO receptors
on: January 7, 2012, 10:08
Quote

out of curiosity, would you or any of your nephrology links know if soluble EPO receptors are dialysable?

Guest

Posts: 176
Permalink
Post Re: Soluble EPO receptors
on: January 7, 2012, 10:17
Quote

Soluble EPO receptors range from 27,000 to 34,000 daltons, depending on the degree of glycosylation. As a reference, beta-microglobulin is 11,000 daltons and albumin is 66,400 daltons.

Most low-flux dialyzers would not clear beta-microglobulin, and thus not clear soluble EPO receptors as well.

High-flux dialyzers, however, can clear beta-microglobulin, but not albumin. Thus, the answer to your question will rest on the type of dialyzer you are using. The manufacturer should specify (in the package insert), the dalton size that it can clear.

Other factors to consider in the clearance of soluble EPO receptors are:
1. volume of distribution
2. half-life of the soluble receptor
3. degree of protein-binding

I hope this helps. For further information click here.

Quick Reply:


Enter Security Code: (required)
Pages: [1]
 ReplyRSS feed   
Mingle Forum by cartpauj
Version: 1.0.34 ; Page loaded in: 0.018 seconds.


Share
  • Nephrology On-Demand Plus


    Our full-featured iOS app for the iPhone and iPad. NOD + integrates
    1. kidney education,
    2. training, and
    3. recruitment

    into a streamlined and user-friendly interface.


    Available_on_the_App_Store_(black)

  • Kidney Konnection


    A newsletter that discusses sophisticated topics in Nephrology for physicians in Internal Medicine.
    Click here to access your complimentary subscription