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Author Topic: Can troponin I be removed by dialysis?

Posts: 219
Post Can troponin I be removed by dialysis?
on: October 12, 2012, 18:52

I know that ESRD patients usually have an elevated troponin at baseline because troponins are usually cleared by the kidneys. What about dialysis? Does dialysis itself remove troponin?



Posts: 219
Post Re: Can troponin I be removed by dialysis?
on: October 12, 2012, 19:02

I was surprised at how difficult it is to find any information about this. I had to query a number of sources to get an answer.

The molecular weight (MW) of troponin I is 23,876 Daltons. For most dialyzers, a middle molecular weight molecule, like vitamin B12, is about 14,800 Daltons. However, the range of "middle molecular weight" molecules is anywhere from 500-60,000 daltons (reference).

Therefore, I'd have to say that Troponins can be cleared by conventional dialyzers.

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