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Author Topic: Amyloidosis & Proteinuria

Posts: 219
Post Amyloidosis & Proteinuria
on: May 13, 2013, 04:19

@kidney_boy and other #nephrology types: AL #amyloid proteinuria due to leakier glomerulus or cub/meg overwhelmed by LC? Or both? do we know?

( Question via Twitter)


Posts: 219
Post Re: Amyloidosis & Proteinuria
on: May 13, 2013, 04:24

Great question. There is actual basement membrane and podocyte destruction seen when amyloid fibrils are deposited. Thus I would favor your second hypothesis as true: that proteinuria develops from "leaky" glomeruli.

Here are 2 classic references for additional reading:

1) http://www.ncbi.nlm.nih.gov/m/pubmed/6478658/

2) http://www.ncbi.nlm.nih.gov/m/pubmed/7216218/?i=3&from=/6478658/related

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