Publications

Adam R. Offenbacher, Anthony T. Iavarone, and Judith P. Klinman. Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase. J. Biol. Chem. In Press

Judith P. Klinman, Adam R. Offenbacher, and Shenshen Hu. The Origins of Enzyme Catalysis: Experimental Findings for C-H Activation, New Models and Their Relevance to Prevailing Theoretical Constructs. J. Am. Chem. Soc. (Perspective) Just Accepted

August 2017: Dr. Offenbacher joins ECU!

Prior Publications:

Adam R. Offenbacher, Shenshen Hu, Erin M. Poss, Cody A. M. Carr, Alexander D. Scouras, Daniil M. Prigozhin, Anthony T. Iavarone, Ali Palla, Tom Alber, James S. Fraser, and Judith P. Klinman. Hydrogen deuterium exchange of lipoxygenase uncovers a relationship between distal, solvent exposed protein motions and the thermal activation barrier for catalytic proton coupled electron tunneling. ACS Cent. Sci. 2017, 3, 570-579.

Masaki Horitani*, Adam R. Offenbacher*, Cody A. M. Carr, Tao Yu, Sharon Hammes-Schiffer, Judith P. Klinman, and Brian M. Hoffman. Active site structure of a  lipoxygenase-substrate complex from 13C ENDOR spectroscopy reveals structural basis for tunneling properties that underlie C-H activation. J. Am. Chem. Soc. 2017, 139, 1984-1997.

Adam R. Offenbacher, Hui Zhu, and Judith P. Klinman. Synthesis of site-specifically 13C labeled linoleic acids. Tetrahedron Lett. 2016, 57, 4537-4540.

Adam R. Offenbacher, Cynthia V. Pagba, Brandon C. Polander, Udita Brahmachari, and Bridgette A. Barry. The first site-specific incorporation of a non-canonical amino acid into the photosynthetic oxygen-evolving complex. ACS Chem. Biol. 2014, 9, 891-896.

Adam R. Offenbacher, R. Atlee Watson, Cynthia V. Pagba, and Bridgette A. Barry. Redox-dependent structural coupling between the a2 and β2 subunits in E. coli ribonucleotide reductase. J. Phys. Chem. B 2014, 118, 2993–3004.

Adam R. Offenbacher, Brandon C. Polander, and Bridgette A. Barry. An intrinsically disordered photosystem II subunit, PsbO, provides a structural template and a sensor of the hydrogen-bonding network in photosynthetic water oxidation. J. Biol. Chem. 2013, 288, 29056-29068.

Adam R. Offenbacher, Ellen C. Minnihan, JoAnne Stubbe, and Bridgette A. Barry. Redox-linked changes to the hydrogen bonding network of ribonucleotide reductase β2. J. Am. Chem. Soc. 2013, 135, 6380–6383.

Adam R. Offenbacher, Lori A. Burns, C. David Sherrill, and Bridgette A. Barry. Redox-linked conformational control of proton-coupled electron transfer: Y122 in the ribonucleotide reductase β2 subunit. J. Phys. Chem. B 2013, 117, 8457–8468.

Bridgette A. Barry, Jun Chen, James Keough, David Jenson, Adam Offenbacher, and Cynthia Pagba. Proton-coupled electron transfer and redox-active tyrosines: Structure and function of the tyrosyl radicals in ribonucleotide reductase and photosystem II. J. Phys. Chem. Lett. 2012, 3, 543-554.

Adam R. Offenbacher, Jun Chen, and Bridgette A. Barry. Perturbations of aromatic amino acids areassociated with iron cluster assembly in ribonucleotide reductase. J. Am. Chem. Soc. 2011, 133, 6978-6988.

Nicholas J. Dunn, William H. Humphries, IV, Adam R. Offenbacher, Travis L. King, and Jeffrey A. Gray. pH-dependent cis –> trans isomerization rates for azobenzene dyes in aqueous solution. J. Phys.Chem. A 2009, 113, 13144–13151.

A. R. Offenbacher, I. R. Vassiliev, M. R. Seyedsayamdost, J. Stubbe, and B. A. Barry. Redox-linked structural changes in ribonucleotide reductase. J. Am. Chem. Soc. 2009, 131, 7496–7497.

Adam Offenbacher, Kimberley N. White, Indranil Sen, Allen G. Oliver, Joseph P. Konopelski,Bridgette A. Barry, and Ólöf Einarsdóttir. A spectroscopic investigation of a tridentate Cu-complex mimicking the tyrosine-histidine cross-link of cytochrome c oxidase. J. Phys. Chem. B 2009, 113, 7407–7417.

Ilya R. Vassiliev, Adam R. Offenbacher, and Bridgette A. Barry. Redox-active tyrosine residues inpentapeptides. J. Phys. Chem. B 2005, 109, 23077–23085